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Use of platelet-rich fibrin as an auxiliary factor in bone healing in maxillofacial and oral surgery
Daniel Ciapiński, Iwona Niedzielska, Andrzej Witowski, Damian Niedzielski
Daniel Ciapiński, Iwona Niedzielska, Andrzej Witowski, Damian Niedzielski
Streszczenie
Fibryna bogatopłytkowa PRF (platelet rich fibrin) znajduje coraz szersze zastosowanie w wielu dziedzinach medycyny, w tym chirurgii, w której istotnym problemem są ubytki i deformacje tkanki kostnej wyrostków zębodołowych szczęki i części zębodołowej żuchwy. Powstają one w następstwie wczesnych ekstrakcji, zabiegów chirurgicznych (resekcje, radektomie, usuwanie zębów zatrzymanych, guzów łagodnych, pozostawionych korzeni, wyłuszczenie torbieli), patologicznych procesów toczących się w okolicy zębów (zespół endo-perio), niewłaściwego wykonania dotychczasowych uzupełnień protetycznych oraz procesów starzenia się. Zanik struktury kostnej wpływa niekorzystnie na ukształtowanie podłoża protetycznego i utrudnia późniejsze leczenie. Metodą z wyboru są techniki augmentacji kości, do których należy sterowana regeneracji kości (guided bone regeneration, GBR), dzięki którym można zapobiegać zanikowi wyrostka. Niewypełnione po ekstrakcji ubytki kostne prowadzą do resorpcji wyrostka zębodołowego.
Celem pracy jest omówienie, dokładna charakterystyka składu oraz analiza właściwości fibryny bogatopłytkowej ze zwróceniem szczególnej uwagi na możliwości jej zastosowania w prewencji zaników kości po ekstrakcji zęba. Autorzy opierają się w swojej pracy na przeglądzie współczesnego piśmiennictwa krajowego i zagranicznego z ostatnich lat.
Hasła indeksowe: fibryna bogatopłytkowa (PRF), sterowana regeneracja kości, czynniki wzrostu
Summary
Platelet rich fibrin (PRF) is becoming more frequently used in many fields of medicine, including surgery, in which a significant problem are defects and deformations of the bony alveolar tissue of the maxilla and mandible. They arise as a sequel to early extraction, surgical procedures (resection, root removal, removal of impacted teeth, benign tumours, retained roots, enucleation of cysts), pathologic processes in the region of the teeth (endo-perio syndrome), inadequately constructed dental prostheses to date and the ageing process. Disappearance of bone structure negatively influences the shape of the denture base and makes future treatment difficult. Methods of choice are techniques of bone augmentation, to which belong guided bone regeneration (GBR), thanks to which alveolar resorption can be prevented. Post extraction tooth loss that is left unfilled lead to resorption of the alveolar crest.
The aim of the study was to accurately describe the characteristics of the composition and analysis of the properties of platelet rich fibrin, with particular attention to the possibilities of its use in the prevention of bone resorption following tooth extraction. The authors base their study on a review of modern Polish and foreign publications over recent years.
Key words: platelet rich fibrin (PRF), guided bone regeneration, growth factors
PIŚMIENNICTWO
1. Chounkroun J. i wsp.: Une opportunité en paro-implantologie: le PRF. Implantodontie, 2001, 42, 55-62.
2. Knighton D.R. i wsp.: Role of platelets and fibrin in the healing sequence: an in vivo study of angiogenesis and collagen synthesis. Ann. Surg., 1982, 196, 4, 379-388.
3. Whitman D.H., Berry R.L., Green D.M.: Platelet gel: an autologus alternative to fibryn glue with applications in oral and maxillofacial surgery. J. Oral Maxillofac. Surg., 1997, 55, 1294-1299.
4. Marx R. i wsp.: Platelet rich plasma growth factors enhancement for bonegrafts. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 1998, 85, 638-646.
5. Dohan D.M. i wsp.: Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2006, 101, 37-44.
6. Dohan D.M. i wsp.: Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2006, 101, 45-50.
7. Dohan D.M. i wsp.: Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2006, 101, 51-55.
8. Chounkroun J. i wsp.: Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2006, 101, 56-60.
9. Chounkroun J. i wsp.: Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2006, 101, 299-303.
10. Carroll R.J. i wsp.: Characterization of autologous growth factors in Cascade platelet rich fibrin matrix (PRFM). Edison NJ: Musculoskeletal Transplant Foundation , 2006, 3, 92-99.
11. Dohan Ehrenfest D.M. i wsp.: Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte- and platelet-rich fibrin (L-PRF). Curr. Pharm. Biotechnol., 2011, 13, 7, 1145-1152.
12. Braccini F., Dohan D.M.: The relevance of Choukroun’s platelet rich fibrin (PRF) during facial aesthetic lipostructure (Coleman’s technique): preliminary results. Rev. Laryngol. Otol. Rhinol., 2007, 128, 255-260.
13. Choukroun, J.I. i wsp.: Influence of platelet rich fibrin (PRF) on proliferation of human preadipocytes and tympanic keratinocytes: a new opportunity in facial lipostructure (Coleman’s technique) and thympanoplasty? Rev. Laryngol. Otol. Rhinol. (Bord.), 2007, 128, 27-32.
14. Sunitha R.V., Munirathnam Naidu E.: Platelet-rich fibrin: evolution of a second-generation platelet concentrate. Indian Dent. Res., 2008, 19, 42-46.
15. Michael Toffler i wsp.: Introducing Choukroun’s platelet rich fibrin (PRF) to the reconstructive surgery milieu. J. Implant Advanced Clin. Dent., 2009, 1, 21-31.
16. Simonpieri A. i wsp.: The relevance of Choukroun’s platelet-rich fibrin and Metronidazole during complex maxillary rehabilitations using bone allograft. Part I: A new rafting protocol. Implant Dent., 2009, 18, 102-111.
17. Simonpieri A. i wsp.: The relevance of Choukroun’s platelet-rich fibrin and Metronidazole during complex maxillary rehabilitations using bone allograft. Part II: Implant surgery, prosthodontics, and survival. Implant Dent., 2009, 18, 220-229.
18. Summers R.B.: A new concept in maxillary implant surgery: the osteotome technique. Compendium, 1994, 15, 152-158.
19. Choi B.H. i wsp.: The use of autologous fibrin glue for closing sinus membrane perforations during sinus lifts. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2006, 101, 150-154.
20. Bok-Joo Kim i wsp.: A comparative study of the effectiveness of sinus bone grafting with recombinant human bone morphogenetic protein 2–coated tricalcium phosphate and platelet-rich fibrin–mixed tricalcium phosphate in rabbits. Oral Maxil. Surg. , 2012, 113, 583-592.
21. Diss A. i wsp.: Osteotome sinus floor elevation using Choukroun’s platelet-rich fibrin as grafting material: a 1-year prospective pilot study with microthreaded implants. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2008, 105, 572-579.
22. Mazor Z. i wsp.: Sinus floor augmentation with simultaneous implant placement using Choukroun’s platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. J. Periodontol., 2009, 80, 2056-2064.
23. Alissa R. i wsp.: The influence of platelet-rich plasma on the healing of extraction sockets: an explorative randomised clinical trial. Eur. J. Oral Implantol., 2010, 3 , 2, 121-134.
24. Barry I.S., Priyu G., Shereen T.: Quantitative evaluation of extraction socket healing following the use of autologous platelet-rich fibrin matrix in humans. Int. J. Periodontics Restorative Dent., 2011, 31, 3, 285-295.
PIŚMIENNICTWO
1. Chounkroun J. i wsp.: Une opportunité en paro-implantologie: le PRF. Implantodontie, 2001, 42, 55-62.
2. Knighton D.R. i wsp.: Role of platelets and fibrin in the healing sequence: an in vivo study of angiogenesis and collagen synthesis. Ann. Surg., 1982, 196, 4, 379-388.
3. Whitman D.H., Berry R.L., Green D.M.: Platelet gel: an autologus alternative to fibryn glue with applications in oral and maxillofacial surgery. J. Oral Maxillofac. Surg., 1997, 55, 1294-1299.
4. Marx R. i wsp.: Platelet rich plasma growth factors enhancement for bonegrafts. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 1998, 85, 638-646.
5. Dohan D.M. i wsp.: Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2006, 101, 37-44.
6. Dohan D.M. i wsp.: Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2006, 101, 45-50.
7. Dohan D.M. i wsp.: Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2006, 101, 51-55.
8. Chounkroun J. i wsp.: Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2006, 101, 56-60.
9. Chounkroun J. i wsp.: Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2006, 101, 299-303.
10. Carroll R.J. i wsp.: Characterization of autologous growth factors in Cascade platelet rich fibrin matrix (PRFM). Edison NJ: Musculoskeletal Transplant Foundation , 2006, 3, 92-99.
11. Dohan Ehrenfest D.M. i wsp.: Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte- and platelet-rich fibrin (L-PRF). Curr. Pharm. Biotechnol., 2011, 13, 7, 1145-1152.
12. Braccini F., Dohan D.M.: The relevance of Choukroun’s platelet rich fibrin (PRF) during facial aesthetic lipostructure (Coleman’s technique): preliminary results. Rev. Laryngol. Otol. Rhinol., 2007, 128, 255-260.
13. Choukroun, J.I. i wsp.: Influence of platelet rich fibrin (PRF) on proliferation of human preadipocytes and tympanic keratinocytes: a new opportunity in facial lipostructure (Coleman’s technique) and thympanoplasty? Rev. Laryngol. Otol. Rhinol. (Bord.), 2007, 128, 27-32.
14. Sunitha R.V., Munirathnam Naidu E.: Platelet-rich fibrin: evolution of a second-generation platelet concentrate. Indian Dent. Res., 2008, 19, 42-46.
15. Michael Toffler i wsp.: Introducing Choukroun’s platelet rich fibrin (PRF) to the reconstructive surgery milieu. J. Implant Advanced Clin. Dent., 2009, 1, 21-31.
16. Simonpieri A. i wsp.: The relevance of Choukroun’s platelet-rich fibrin and Metronidazole during complex maxillary rehabilitations using bone allograft. Part I: A new rafting protocol. Implant Dent., 2009, 18, 102-111.
17. Simonpieri A. i wsp.: The relevance of Choukroun’s platelet-rich fibrin and Metronidazole during complex maxillary rehabilitations using bone allograft. Part II: Implant surgery, prosthodontics, and survival. Implant Dent., 2009, 18, 220-229.
18. Summers R.B.: A new concept in maxillary implant surgery: the osteotome technique. Compendium, 1994, 15, 152-158.
19. Choi B.H. i wsp.: The use of autologous fibrin glue for closing sinus membrane perforations during sinus lifts. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2006, 101, 150-154.
20. Bok-Joo Kim i wsp.: A comparative study of the effectiveness of sinus bone grafting with recombinant human bone morphogenetic protein 2–coated tricalcium phosphate and platelet-rich fibrin–mixed tricalcium phosphate in rabbits. Oral Maxil. Surg. , 2012, 113, 583-592.
21. Diss A. i wsp.: Osteotome sinus floor elevation using Choukroun’s platelet-rich fibrin as grafting material: a 1-year prospective pilot study with microthreaded implants. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2008, 105, 572-579.
22. Mazor Z. i wsp.: Sinus floor augmentation with simultaneous implant placement using Choukroun’s platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. J. Periodontol., 2009, 80, 2056-2064.
23. Alissa R. i wsp.: The influence of platelet-rich plasma on the healing of extraction sockets: an explorative randomised clinical trial. Eur. J. Oral Implantol., 2010, 3 , 2, 121-134.
24. Barry I.S., Priyu G., Shereen T.: Quantitative evaluation of extraction socket healing following the use of autologous platelet-rich fibrin matrix in humans. Int. J. Periodontics Restorative Dent., 2011, 31, 3, 285-295.
