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Bisphosphonates related-osteonecrosis of the jaw as a result of tooth extraction – short characteristics and case description
Damian Dudek, Edyta Reichman-Warmusz, Andrzej Gruźlewski, Marta Nowak
Streszczenie
W pracy przedstawiono potwierdzony histopatologicznie przypadek zapalenia kości wyrostka zębodołowego szczęki lewej podczas stosowania bisfosfonianów. Zapalenie wystąpiło około 4 tygodni po usunięciu zęba 28, doprowadzając do wydzielenia się po trzech miesiącach martwaka kostnego. Odnotowano ponadto miejscowe i ogólne objawy zapalne. Zastosowano leczenie farmakologiczne i chirurgiczne, uzyskując regresję objawów, jednak zapalenie doprowadziło do prawie całkowitego zaniku masy kostnej wyrostka zębodołowego szczęki lewej w odcinku bocznym.
Abstract
The article presents a histopathologically confirmed case of bisphosphonate related osteonecrosis of the left alveolar bone. Inflammation occurred about 4 weeks after the extraction of tooth 28, leading to the extrusion of bone secfestor after three months. There were also local and general inflammatory symptoms. Pharmacological and surgical treatment has been used to obtain symptomatic regression, but inflammation has led to almost complete defect of the alveolar bone in the left maxillary.
Hasła indeksowe: bisfosfonianowe zapalenie kości, leczenie systemowe
Key words: bisphosphonates related osteonecrosis of the jaws, systematic treatment
PIŚMIENNICTWO
1. Panaś M., Zaleska M., Kaczmarzyk T.: Patient undergoing bisphosphonate therapy at the dental surgery. J. Stoma., 2013, 66, 710-720.
2. Ruggiero S.L., Fantasia J., Carlson E.: Bisphosphonate-related osteonecrosis of the jaws: background and guidelines for diagnosis, staging and management. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2006, 102, 433-441.
3. Kimmel D.B.: Mechanism of action, pharmacokinetic and pharmacodynamic profile and clinical applications of nitrogen-containing bisphosphonates. J. Dent. Res., 2007, 86, 1022-1033.
4. Ruggiero S.L., Drew S.J.: Osteonecrosis of the jaws and bisphosphonate therapy. J. Dent. Res., 2007, 86, 1013-1021.
5. Rizzoli R., Burlet N., Cahall D. i wsp.: Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis. Bone, 2008, 42, 841-847.
6. Malden N., Beltes C., Lopes V.: Dental extractions and bisphosphonates: the assessment, consent and management, a proposed algorithm. Br. Dent. J., 2009, 206, 93-98.
7. Schubert M., Klatte I., Linek W. i wsp.: The Saxon Bisphosphonate Register – therapy and prevention of bisphosphonate-related osteonecrosis of the jaws. Oral Oncol., 2012, 48, 4, 349-354.
8. Carlson E.R., Basile J.D.: The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws. J. Oral Maxillofac. Surg., 2009, 67, 85-95.
9. Freiberger J.J.: Utility of hyperbaric oxygen treatment of bisphosphonate-related osteonecrosis of the jaws. J. Oral Maxillofac. Surg., 2009, 67, 96-106.
10. Marx R.E., Cillo J.E., Ulloa J.J.: Oral biphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention and treatment. J. Oral Maxillofac. Surg., 2007, 65, 2397-2410.
11. Taylor T., Bryant C., Popat S.: A study of 225 patients on bisphosphonates presenting to the bisphosphonate clinic at King’s College Hospital. Br. Dent. J., 2013, 214, E18.
12. Carlson E.R., Basile J.D.: The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws. J. Oral Maxillofac. Surg., 2009, 67, 85-95.
13. Jeon H.G., Hwang J.J., Lee J.H. i wsp.: Risk factors of osteonecrosis of the jaw after tooth extraction in osteoporotic patients on oral bisphosphonates. Imaging Sci. Dent., 2017, 47, 45-50.
14. Jiaxing G., Huiming W.: Clinical analysis of bisphosphonate-related osteonecrosis of the jaw. Hua Xi Kou Qiang Yi Xue Za Zhi, 2016, 34, 358-363.
15. Guo Y., Wang D., An J. i wsp.: Clinical analysis of 24 cases of bisphosphonate-related osteonecrosis of the jaw. Zhonghua Kou Qiang Yi Xue Za Zhi, 2014, 49, 517-520.
16. Otto S. i wsp.: Tooth extraction in patients receiving oral or intravenous bisphosphonate administration: a trigger for BRONJ development? J. Craniomaxillofac. Surg., 2015, 43, 847-854.
Damian Dudek, Edyta Reichman-Warmusz, Andrzej Gruźlewski, Marta Nowak
Streszczenie
W pracy przedstawiono potwierdzony histopatologicznie przypadek zapalenia kości wyrostka zębodołowego szczęki lewej podczas stosowania bisfosfonianów. Zapalenie wystąpiło około 4 tygodni po usunięciu zęba 28, doprowadzając do wydzielenia się po trzech miesiącach martwaka kostnego. Odnotowano ponadto miejscowe i ogólne objawy zapalne. Zastosowano leczenie farmakologiczne i chirurgiczne, uzyskując regresję objawów, jednak zapalenie doprowadziło do prawie całkowitego zaniku masy kostnej wyrostka zębodołowego szczęki lewej w odcinku bocznym.
Abstract
The article presents a histopathologically confirmed case of bisphosphonate related osteonecrosis of the left alveolar bone. Inflammation occurred about 4 weeks after the extraction of tooth 28, leading to the extrusion of bone secfestor after three months. There were also local and general inflammatory symptoms. Pharmacological and surgical treatment has been used to obtain symptomatic regression, but inflammation has led to almost complete defect of the alveolar bone in the left maxillary.
Hasła indeksowe: bisfosfonianowe zapalenie kości, leczenie systemowe
Key words: bisphosphonates related osteonecrosis of the jaws, systematic treatment
PIŚMIENNICTWO
1. Panaś M., Zaleska M., Kaczmarzyk T.: Patient undergoing bisphosphonate therapy at the dental surgery. J. Stoma., 2013, 66, 710-720.
2. Ruggiero S.L., Fantasia J., Carlson E.: Bisphosphonate-related osteonecrosis of the jaws: background and guidelines for diagnosis, staging and management. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2006, 102, 433-441.
3. Kimmel D.B.: Mechanism of action, pharmacokinetic and pharmacodynamic profile and clinical applications of nitrogen-containing bisphosphonates. J. Dent. Res., 2007, 86, 1022-1033.
4. Ruggiero S.L., Drew S.J.: Osteonecrosis of the jaws and bisphosphonate therapy. J. Dent. Res., 2007, 86, 1013-1021.
5. Rizzoli R., Burlet N., Cahall D. i wsp.: Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis. Bone, 2008, 42, 841-847.
6. Malden N., Beltes C., Lopes V.: Dental extractions and bisphosphonates: the assessment, consent and management, a proposed algorithm. Br. Dent. J., 2009, 206, 93-98.
7. Schubert M., Klatte I., Linek W. i wsp.: The Saxon Bisphosphonate Register – therapy and prevention of bisphosphonate-related osteonecrosis of the jaws. Oral Oncol., 2012, 48, 4, 349-354.
8. Carlson E.R., Basile J.D.: The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws. J. Oral Maxillofac. Surg., 2009, 67, 85-95.
9. Freiberger J.J.: Utility of hyperbaric oxygen treatment of bisphosphonate-related osteonecrosis of the jaws. J. Oral Maxillofac. Surg., 2009, 67, 96-106.
10. Marx R.E., Cillo J.E., Ulloa J.J.: Oral biphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention and treatment. J. Oral Maxillofac. Surg., 2007, 65, 2397-2410.
11. Taylor T., Bryant C., Popat S.: A study of 225 patients on bisphosphonates presenting to the bisphosphonate clinic at King’s College Hospital. Br. Dent. J., 2013, 214, E18.
12. Carlson E.R., Basile J.D.: The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws. J. Oral Maxillofac. Surg., 2009, 67, 85-95.
13. Jeon H.G., Hwang J.J., Lee J.H. i wsp.: Risk factors of osteonecrosis of the jaw after tooth extraction in osteoporotic patients on oral bisphosphonates. Imaging Sci. Dent., 2017, 47, 45-50.
14. Jiaxing G., Huiming W.: Clinical analysis of bisphosphonate-related osteonecrosis of the jaw. Hua Xi Kou Qiang Yi Xue Za Zhi, 2016, 34, 358-363.
15. Guo Y., Wang D., An J. i wsp.: Clinical analysis of 24 cases of bisphosphonate-related osteonecrosis of the jaw. Zhonghua Kou Qiang Yi Xue Za Zhi, 2014, 49, 517-520.
16. Otto S. i wsp.: Tooth extraction in patients receiving oral or intravenous bisphosphonate administration: a trigger for BRONJ development? J. Craniomaxillofac. Surg., 2015, 43, 847-854.
